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Wadden has received grants and consulting fees from Novo Nordisk

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Its effects cascade through growth hormone and subsequently IGF-1 pathways to influence fat metabolism, protein synthesis, and tissue repair

[DOI] [PMC free article] [PubMed] [Google Scholar] 128.Porcu M., Urbano M.R., Verri W.A., Jr, Barbosa D.S., Baracat M., Vargas H.O., Machado R.C.B.R., Pescim R.R., Nunes S.O.V

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HDAC inhibition increases acetylation of the NR3C1 gene (encoding the glucocorticoid receptor), enhancing glucocorticoid receptor sensitivity and restoring the negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis